Th2 Differentiation Pathway
Click on one of the links shown in the Explore Pathways box below to see the processes that promote Th2 differentiation and the transcription factors, secreted molecules, and some of the cell surface markers that distinguish a differentiated Th2 cell from the other T helper cell subtypes.
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Overview of Th2 Differentiation
CD4+ T cells play a central role in the adaptive immune response. They are critically involved in recruiting and activating other immune cells, dampening ongoing immune responses, and maintaining immunologic memory. Following T cell receptor activation and co-stimulation by antigen-presenting cells (APC), naïve CD4+ T cells differentiate into one of several lineages of T helper cell subtypes. These subsets express characteristic combinations of transcription factors, cell surface proteins, and secreted molecules. T helper type 2 (Th2) cells provide host protection against intestinal helminths and extracellular bacteria in addition to support for B cell-dependent humoral responses. Pathological Th2 cell activity is a hallmark of allergic inflammation and asthma.
To learn more, please visit our Th2 Cells Research Area.
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